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This Concept Map, created with IHMC CmapTools, has information related to: Matthew, splenomegaly splenic sequestration Neutropenia, ↑KB ketoacidosis ↓ Bl. pH, hepatomegaly portal hypertension splenomegaly, ↓ hematocrit ↓ O2 transport ↓ Muscle O2, Lung infection causes ↓ O2 exchange in lungs, ↓ Bl. Glucose stimulates seizures, Type 1B G6Pase Disorder causes Ineffective Gluconeogensis, Neutropenia increases risk Lung infection, ↓ Bl. pH compensatory response tachypnea, ↓ Bl. Glucose chronic hemolytic anemia ↓ hematocrit, Ineffective Gluconeogensis causes ↓ Bl. Glucose, Type 1B G6Pase Disorder causes Ineffective Glycogenolyis, Ineffective Glycogenolyis causes ↑ Glycogen Storage, ↓ Muscle O2 anerobic glycolysis ↑ Pl. Lactate, Matthew G6P transport defect Type 1B G6Pase Disorder, ↓ Bl. pH vomiting tries to ↑ Bl. pH vomiting, tachypnea abnormal gas exchange ↓ Bl. CO2, ↑Epinephrine vasoconstriction Cool/Clammy skin, Lung infection causes Fever, ↑ G6P increases pyruvate