Conjugated Estrogens (premarin)

hormone replacement therapy / prevent ovulation, increase risk of clotting, decrease risk for many cancers, increase risk for breast Ca 1.5 x

Side effects: weight gain, nausea, gall bladder, mood changes

Contraindications: pregnancy, breast cancer, heart disease, stroke, liver disease, migraines

Drug interactions:  phenytoin/phenobarbital increase metabolism, rifampycin decreasing recyling (both increase clearance)

Dosing: 0.625 mg/d for replacement therapy