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This Concept Map, created with IHMC CmapTools, has information related to: CBL A1 Hyperthermia, skin decreasing body temperature, <math xmlns="http://www.w3.org/1998/Math/MathML"> <mrow> <mmultiscripts> <mtext> Na </mtext> <none/> <mtext> + </mtext> </mmultiscripts> <mtext> and </mtext> <mmultiscripts> <mtext> K </mtext> <none/> <mtext> + </mtext> </mmultiscripts> <mtext> leak channels </mtext> </mrow> </math> cause change in cell membrane potential, hyperactivity of nicotinic Ach receptor causes prolonged depolarization, malignant hyperthermia clinically presents as sustained muscle contraction, carbonic acid resulting in acidosis, pH of 7.2 diagnostic of acidosis, myosin resulting in muscle contraction, O2 leading to anaerobic metabolism, production of CO2 limiting presence of O2, Neuromuscular junction causing Increase of Ca2+ permeability, prolonged depolarization causes muscle fasiculation, ATP causing generation of heat, Increase of Ca2+ permeability in Motor Neuron, aerobic metabolism increasing production of CO2, muscle cell including cardiac muscle, sympathetic branch of ANS leads to Excretion of sweat, anaerobic metabolism increasing lactate, opening of Na voltage gated channels causing Depolarization of the membrane, Nick Thermopolis admitted to ICU for body temperature, mivacurium block nicotinic Ach receptor activity