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11,655 results

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Quoted phrase not found in phrase index: "prostaglandin-endoperoxide synthase"
Page 1
Non-steroidal anti-inflammatory drugs and the gastrointestinal tract.
Tai FWD, McAlindon ME. Tai FWD, et al. Clin Med (Lond). 2021 Mar;21(2):131-134. doi: 10.7861/clinmed.2021-0039. Clin Med (Lond). 2021. PMID: 33762373 Free PMC article.
Selective cyclo-oxygenase (COX)-2 inhibitors are as effective as adding PPIs in preventing upper and lower gastrointestinal complications. COX-2 inhibitors are suggested in those with high cardiovascular risk and the addition of PPI in those with high …
Selective cyclo-oxygenase (COX)-2 inhibitors are as effective as adding PPIs in preventing upper and lower gastrointestinal co …
COX Inhibitors.
Qureshi O, Dua A. Qureshi O, et al. 2024 Feb 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2024 Feb 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31747202 Free Books & Documents.
This program thoroughly explores the pivotal role of COX inhibitors in managing chronic pain syndromes across diverse disease spectrums. As indispensable anti-inflammatory agents, COX inhibitors significantly contribute to alleviating pain associated w …
This program thoroughly explores the pivotal role of COX inhibitors in managing chronic pain syndromes across diverse disease …
Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond.
Rao P, Knaus EE. Rao P, et al. J Pharm Pharm Sci. 2008 Sep 20;11(2):81s-110s. doi: 10.18433/j3t886. J Pharm Pharm Sci. 2008. PMID: 19203472 Free article. Review.
RESULTS: A brief history of the development of NSAIDs and the market withdrawal of selective COX-2 inhibitors is explained, followed by the description of prostaglandin biosynthesis, COX isoforms, structure and function. ...This is followed by a section that …
RESULTS: A brief history of the development of NSAIDs and the market withdrawal of selective COX-2 inhibitors is explained, fo …
A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation.
Yang HH, Duan JX, Liu SK, Xiong JB, Guan XX, Zhong WJ, Sun CC, Zhang CY, Luo XQ, Zhang YF, Chen P, Hammock BD, Hwang SH, Jiang JX, Zhou Y, Guan CX. Yang HH, et al. Theranostics. 2020 Mar 26;10(11):4749-4761. doi: 10.7150/thno.43108. eCollection 2020. Theranostics. 2020. PMID: 32308747 Free PMC article.
Methods: The metabolism of CYPs/COX-2-derived ARA in the lungs of LPS-induced ALI was investigated in C57BL/6 mice. The COX-2/sEH dual inhibitor PTUPB was used to establish the function of CYPs/COX-2 dysregulation in ALI. ...
Methods: The metabolism of CYPs/COX-2-derived ARA in the lungs of LPS-induced ALI was investigated in C57BL/6 mice. The COX-2/ …
Colorectal Carcinoma, Cyclooxygenases, and COX Inhibitors.
Ganduri V, Rajasekaran K, Duraiyarasan S, Adefuye MA, Manjunatha N. Ganduri V, et al. Cureus. 2022 Aug 30;14(8):e28579. doi: 10.7759/cureus.28579. eCollection 2022 Aug. Cureus. 2022. PMID: 36185863 Free PMC article. Review.
Therefore, COX inhibition by non-steroidal anti-inflammatory drugs (NSAIDs) targeted against both the isoforms COX-1 and COX-2 have been studied for decades in anticipation of preventing the occurrence of colorectal carcinoma in high-risk populations. This ar …
Therefore, COX inhibition by non-steroidal anti-inflammatory drugs (NSAIDs) targeted against both the isoforms COX-1 and CO …
COX-2 Inhibitors and Gastric Cancer.
Wang Z, Chen JQ, Liu JL. Wang Z, et al. Gastroenterol Res Pract. 2014;2014:132320. doi: 10.1155/2014/132320. Epub 2014 Oct 12. Gastroenterol Res Pract. 2014. PMID: 25371669 Free PMC article. Review.
Both COX-dependent and COX-independent pathways have a role in the anticancer efficiency of COX-2 inhibitors. However, enthusiasm is thwarted by the potential toxicity, that is, gastrointestinal toxicity of nonselective COX-2 inhibitors a …
Both COX-dependent and COX-independent pathways have a role in the anticancer efficiency of COX-2 inhibitors. Ho …
Thiazoles and Thiazolidinones as COX/LOX Inhibitors.
Liaras K, Fesatidou M, Geronikaki A. Liaras K, et al. Molecules. 2018 Mar 18;23(3):685. doi: 10.3390/molecules23030685. Molecules. 2018. PMID: 29562646 Free PMC article. Review.
Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of prostaglandin …
Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, as …
Role of Cyclooxygenase-2 in colorectal cancer patients.
Nanda N, Dhawan DK. Nanda N, et al. Front Biosci (Landmark Ed). 2021 Jan 1;26(4):706-716. doi: 10.2741/4914. Front Biosci (Landmark Ed). 2021. PMID: 33049690 Free article. Review.
Consistent with such a conceptual framework, it has been shown that COX-2 inhibitors prevent the carcinogenesis of CRC and aid in the treatment of sporadic or familial cases of CRC as shown by an overall increase in the survival rate. However, prolonged use of these …
Consistent with such a conceptual framework, it has been shown that COX-2 inhibitors prevent the carcinogenesis of CRC and aid …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective.
Chahal S, Rani P, Kiran, Sindhu J, Joshi G, Ganesan A, Kalyaanamoorthy S, Mayank, Kumar P, Singh R, Negi A. Chahal S, et al. ACS Omega. 2023 May 9;8(20):17446-17498. doi: 10.1021/acsomega.3c00692. eCollection 2023 May 23. ACS Omega. 2023. PMID: 37251190 Free PMC article. Review.
Nevertheless, there is mounting evidence of cardiovascular side effects from COX-II inhibitors that resulted in the withdrawal of market-approved anti-COX-II drugs. ...To address this gap, herein we present an overview of chemical structures and inhibitory ac …
Nevertheless, there is mounting evidence of cardiovascular side effects from COX-II inhibitors that resulted in the withdrawal …
Prostaglandin E2 Signaling: Alternative Target for Glioblastoma?
Jiang J, Qiu J, Li Q, Shi Z. Jiang J, et al. Trends Cancer. 2017 Feb;3(2):75-78. doi: 10.1016/j.trecan.2016.12.002. Epub 2017 Jan 11. Trends Cancer. 2017. PMID: 28718447 Free PMC article. Review.
Elevated cyclooxygenase-2 (COX-2) and the associated inflammation within the brain contribute to glioblastoma development. However, medical use of COX inhibitors in glioblastoma treatment has been limited due to their well-documented vascular toxicity and inc …
Elevated cyclooxygenase-2 (COX-2) and the associated inflammation within the brain contribute to glioblastoma development. However, m …
11,655 results
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