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This Concept Map, created with IHMC CmapTools, has information related to: PDC_GroupMap, Pyruvate Dehydrogenase Kinase leading to a decrease in Phosphorylation, Phosphorylation allows for activity of the Pyruvate Dehydrogenase Complex, ATP/ADP ratio which inactivates Pyruvate Dehydrogenase Kinase, oxidative phosphorylation resulting in decreased NADH/NAD ratio, Mother 26 years old gives birth to Ann, gluconeogenesis in Liver, gluconeogenesis in Kidney, E1 alpha protein detected by Western Blot indicate Normal size PDC protein, Phosphorylation allows for activity of the Pyruvate Dehydrogenase Complex, Neurological Disorders in Elizabeth, E1 alpha subunit of the Pyruvate Dehydrogenase Complex, missense point mutation of E1 alpha subunit, Pyruvate Carboxylase which requires the cofactor Biotin, Acetyl CoA low levels of which allosterically activates Pyruvate Carboxylase, Pyruvate Dehydrogenase Complex gene for which is located on the X chromosome, Mitochondria to provide substrates for TCA Cycle, Mother 26 years old gives birth to Elizabeth, ATP perfered energy source of the Brain, Pyruvate Dehydrogenase Complex impairment affects conversion of Pyruvate, High Ketone Diet leads to production of Ketone Bodies