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This Concept Map, created with IHMC CmapTools, has information related to: PDC Deficiency final rev, Oxaloacetate which is a substrate that can be used in TCA cycle, Pyruvate Dehydrogenase Kinase leading to a decrease in Phosphorylation, Pyruvate Dehydrogenase Complex impairment affects conversion of Pyruvate, X chromosome mutation is transmitted as X-linked, ATP formed from Glucose perfered energy source of the Brain, gluconeogenesis in Liver, oxidative phosphorylation decreasing the concentrations ATP formed from Glucose, Phosphorylation allows for activity of the Pyruvate Dehydrogenase Complex, NADH/NAD ratio which normally inactivates Pyruvate Dehydrogenase Kinase, Blood glucose leading to increased production of Pyruvate, Pyruvate Dehydrogenase Kinase leading to a decrease in Phosphorylation, High Ketone Diet leads to production of Ketone Bodies, Phosphorylation allows for activity of the Pyruvate Dehydrogenase Complex, Phosphorylation allows for activity of the Pyruvate Dehydrogenase Complex, oxidative phosphorylation forming ATP, Lyonization which is defined as the random inactivation of one X chromosome during embryonic development, gluconeogenesis in Kidney, Brain resulting in Neurological Disorders, Pyruvate Dehydrogenase Kinase leading to a decrease in Phosphorylation, Disease Management includes treatment with Thiamine