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This Concept Map, created with IHMC CmapTools, has information related to: CBL A1 Dyspnea I, CD 4 T-cells (naive) differentiate to Th-2, B-cells (naive) presents Ag to CD 4 T-cells (naive), B-cells produce IgE for repeated exposure, cytokines attract macrophages, chemokines attract macrophages, IgE for repeated exposure activates mast cells, B-cells produce IgM for 1st exposure, immunocytes increase vasopermeability, Ag presenting cells such as dendritic cells, accessory respiratory muscles which expand chest wall, neutrophils are immunocytes, Denis Asner presents with wheezing, chest wall decreases intrapleural pressure, airflow resistance chronic increase causes chest expansion, eosinophils releases cytokines, mast cells release heparin, immunocytes increase smooth muscle contraction, NO causes vasodilation, allergen phagocytosed by Ag presenting cells, smooth muscle contraction causes bronchoconstriction