WARNING:
JavaScript is turned OFF. None of the links on this concept map will
work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: TangiersII, ABCA1 lack of causes failure to lipidate Apo AI, autosomal codominant resulting in varying expression of ABCA1, lipoprotein lipase in hetero activated and proceeds with CETP, Oxidized LDL with build up triggers inflamation response attracting arterial macrophages, apoC-II is carried by HDL, autosomal codominant phenotypes vary with heterozygotes, Tissue Macrophages form foam cells, tissue hyperplasia seen clinically as enlarged tonsils, CETP when defective results in low cholesterol transfer from HDL to VLDL, arterial macrophages when injesting oxidized LDL, results in foam cells, HDL allows for removal of Cholesterol ester, TAGs from VLDL, foam cells build up of leads to tissue hyperplasia, Cholesterol ester from HDL is taken up in liver by SR-B1, VLDL contains Apo B100, familial HDL deficiency could result in Coronary artery disease, arterial epithelial cells resulting in decreased cell endocytosis of circulating LDL, ABCA1 allele allows for some production of HDL, cholesterol not removed by HDL as CE leading to build up in tonsils and phagocytosis by Tissue Macrophages, ABCA1 allele which allows some functioning of CETP