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This Concept Map, created with IHMC CmapTools, has information related to: Hyperhomocysteinemia-jeff, ROS resulting in Compromised NT production, betaine homocysteine methyltransferase forming methionine, Cystathionine is converted by Gamma Cystathionase, Homocysteine is a Highly reactive AA, S-adenosylmethionine (SAM) is converted by methyltranferase to S-Adenosylhomocysteine (SAH), Vitamin B6 to form Cystathionine, Compromised NT production leading to neurological disease, 5,10 MTHFR to 5-methyltetrahydrofolate (Dietary folate), 5-methyltetrahydrofolate (Dietary folate) which donates a methyl group, methyl by betaine homocysteine methyltransferase, Vascular Disease including Stroke, Cystathionine beta-Synthase uses Vitamin B6, cysteine using Vitamin B6, endothelial damage causing Vascular Disease, betaine which donates a methyl, methyl group to Cobalimin, C677 --> T mutation variant of 5,10 MTHFR, 5,10 methylenetetrahydrofolate converted by 5,10 MTHFR, methionine is converted by methionine adenosyltransferase S-adenosylmethionine (SAM), Homocysteine in urine leading to the diagnosis of Homocysteinuria