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This Concept Map, created with IHMC CmapTools, has information related to: T cell responses (6).cmap, macrophages enhance Selected cytokine chemokine production, CD4+ T cells leads to CD3, CD4+ T cells express CD4, selected transcription factiors including NF-kB lead to CD40 Ligand (CD154), macrophages release IL-12, Th1 release IL-2, CD4 recognizes MHC II, Th1 release TNF-alpha, selected transcription factiors including NF-kB lead to production of IL-2, TCRs recognize Ag peptide, MHC II presents Ag peptide, Mast cells release IL-5, B cells undergo Clonal expansion, Signal #2 implication in Vaccine development (Adjuvant), APCs express B7 (B7.1 and B7.2), IL-4 promotes differenciation of Th2, IL-13 inhibits differenciation of Th1, B cells undergo Isotype switching affinity maturation, Th2 releases IL-10, IL-5 recriuts Mast cells