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Miller hyperthermia, causes conformational change in L type Ca channel causes opening via A site RYR 1 in SR of skeletal muscle, succinyl choline individuals w/ mutations ↑ A site affinity, depletion of ATP causes damage to muscle cells, acetyl choline binds to Ach receptor on Skeletal Muscle influx of cations, myoglobin cross reacts w/ dipstick reagent false + test result for Bl. in urine, kidney damage characterized by ↓ Urine formation, succinyl choline binds to nicotinic receptors, RYR 1 in SR of skeletal muscle normal I site, nueromuscular junction release acetyl choline, ↓ Affinity [Ca++] ???? ????