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Too much of a good thing, ↓ Glutamate decrease excitability, lower motor (alpha) nueron damage/death causes denervation of muscle fibers, compensatory hypertrophy of innervated and reinervated fibers results ↑ Amplitude and duration in EMG tests, gain of function leads to ↓ in antioxidant activity, denervation of muscle fibers causes spreading of AChR on sarcolemma, Riluzole antagonist NMDA channel, Mrs. Alston mutation in SOD1 gain of function, apoptosis (motor pathways) causes lower motor (alpha) nueron damage/death, apoptosis (motor pathways) causes upper motor nueron death/damage, ↑ free radicals causes apoptosis (motor pathways)