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This Concept Map, created with IHMC CmapTools, has information related to: Pt of Origin 2, OF 46 yof right handed has Stage 3 Ovarian Cancer, APC activate CD4T cells in periphery cross talk activates CD8+ T cells Some of which both CD4+ and CD8+ are capable of crossing BBB when activated, Purkinje Fibers in Lateral Cortex, IL 10, IL-2, INF alpha all act on endothelial cells to increase permeability of BBB as a result more T cells , monocytes, and Ab can cross the BBB, CD4+ T cells secrete proinfamitory cytokines also activate resident microglial cells to begin antigen presentation IL 10, IL-2, INF alpha all act on endothelial cells to increase permeability of BBB, OF 46 yof right handed has symptoms of ataxia, cells respond to aberrant activation induces apoptosis, Spinal input from the ventral-spino cerebellar tract about the motor comand recieved by the alpha motor neuorons as well as proprioceptive information from the dorsal-spino cerebellar tract (legs) and cuneo-crebellar tract (arms), OF 46 yof right handed has symptoms of disarthria, alcohol keeps GABA channels open allowing increased inhibitory effect of GABA, more T cells , monocytes, and Ab can cross the BBB cross react with Yo protein that is expressed on Purkinje cells abnormally, alcohol worsens disarthria, dsirupts YO-c-Myc interaction leads to increased c-Myc activity cells respond to aberrant activation, Lateral Cortex resulting in reduced firing of purkinje cells, Purkinje Fibers which project to the deep nuclei of the cerebellum, alcohol worsens ataxia, which includes the protein Yo activates immune response APC activate CD4T cells in periphery, Lateral Cortex receives Cortical input, copies of the motor comand, Cortical input, copies of the motor comand which has a topography which is skewed towards the limbs and hands, Some of which both CD4+ and CD8+ are capable of crossing BBB when activated T cell crosses BBB CD4+ T cells secrete proinfamitory cytokines