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This Concept Map, created with IHMC CmapTools, has information related to: Depression, reduction to higher cortical areas results in concentration, Depression caused by genetics, Depression causes changes in the brain decrease of oligodendrocytes, Depression caused by environmental stress, cerebral blood flow changes results in increased to central brain, Depression caused by other psychological conditions, Depression causes changes in the brain increased amounts of cortisol, Depression show disturbances of 4 concentration, Depression caused by disease, Depression show disturbances of 4 mood, Depression causes changes in the brain changes in brain glucose metabolism, Depression causes changes in the brain cerebral blood flow changes, decrease of oligodendrocytes casues changes in response to reduction in brain system activity involving serotonin neurons, Depression show disturbances of 4 interest, Depression show disturbances of 4 appetite, Depression show disturbances of 4 energy, Depression show disturbances of 4 sleep, genetics ???? mutation in TPH2 gene, reduction in brain system activity involving serotonin neurons may be caused by mutation in TPH2 gene, Depression show disturbances of 4 pleasure enjoyment