Could Mr. C’s foot numbness be related to his stoke? What other causes could there be for this pattern of numbness? There is the possibility that Mr. C’s foot numbness could be related to his stroke; however, this numbness is most likely related to diabetic neuropathy given his past health history. Neuropathic pain is the result of trauma or disease of nerves and leads to abnormal processing of sensory information by the peripheral and central nervous systems (McCance & Heuther, 2006). Diabetic neuropathy is seen in older diabetic patients and is a result of micro-vascular injury to the small blood vessels that supply the nerves of the periphery (i.e. hands and feet) (McCance & Heuther, 2006; Up to Date, 2008). Diabetic neuropathy is primarily a symmetrical sensory neuropathy, initially affecting the distal lower extremities (Up to Date), as evidenced by Mr. C. In addition, Mrs. C has stated that her husband’s “sugars” have been “out of control” which indicates the potential for increased micro- vascular damage and development of neuropathies. A less likely cause of Mr. C’s neuropathy includes previous chemotherapy treatment, especially with vinca alkaloid drugs. This chemotherapy regime may be associated with a variety of neuropathies producing painful sensations in the hands and feet (McCance & Heubert, 2006). References McCance, K. L., & Heuther, S. E. (2006). Pathophysiology: The biological basis for disease in adults and children. Elsivier Mosby: Philadelphia. Up to Date. (2008). Seizure disorders. Retrieved from www.uptodate.com. May 26, 2008.