Warning:
JavaScript is turned OFF. None of the links on this page will work until it is reactivated.
If you need help turning JavaScript On, click here.
The Concept Map you are trying to access has information related to:
Antigen Presentation, Transporters assoc'd w/ AG Processing TAP1, TAP2- ABC(require ATP) heterodimer=TAP complex along ER membrane -bind to nascent MHC Class I via tapasin Proteasome 4 stacked 7-subunit rings=28 subunits -cytosolic protease -hollow core lined by active subunits -2 subunits MHC-encoded (b1i, b5i) -upregulated by IFNs (so is b2i) -these 3 replace subunits in const. prot. 2 types-constitutive, immunoproteasome ->increased cleavage of basic, hydrophobic residues when induced -carboxy-terminus preferred by MHC-I IFN-g-induced PA28alpha and PA28beta -open up immunoproteasome to inc. efflux, TCR (alpha:beta heterodimer) -binds peptide:MHC ligand -no inherent signaling CD3 complex-4 signaling chains zeta-chain homodimer (6 ITAMS) -ᡂ ITAMS total T Cell Signaling TCRs/co-receptors cluster ->initiate signaling ->recruit Lck ->activate Fyn (Src family) ->phos'ate ITAMs on zeta, CD3 ->ZAP-70 (Tyr Kinase) binds to zeta ITAMs ->ZAP-70 phos'ated by Lck ->ZAP-70 phos'ates LAT, SLP-76 ->SLP-76 activates PLC, GEFs, Tec kinases, pH in endocytic vesicles decreases ->acidifies, activating proteases ->degrade engulfed material -GILT reduces disulfide bonds (IFNg-induced) MHC-II pass through vesicles, pick up peptide en route to membrane MHC-II Production Invariant chain (Ii) binds MHC-II active site -while in ER, calnexin binds -CLIP lies along groove -trimeric (3 MHC-IIs to 1 Ii) ->prevent binding of random peptides ->target MHC-II to acidic endosome there, Cathepsin clips, leaving CLIP possible fusion of MHC-II vesicles w/ endosomes -compartment is MIIC-late in endosome pathway, Signaling G proteins Ras-small G protein -binds GTP -with GTPase, cleave GTP ->GDP -use Guanine-Nuc Exchange Factor (GEF)->displace GDP ->allow GTP to bind, Signaling TCR Complex TCR (alpha:beta heterodimer) -binds peptide:MHC ligand -no inherent signaling CD3 complex-4 signaling chains zeta-chain homodimer (6 ITAMS) -ᡂ ITAMS total, GEFs activate Ras, Rac ->activate MAP kinase cascade ->activate Fos->AP-1 x-factor Then Specific Gene xscription ->cell proliferation and diff'ation, Ig_alpha,beta heterodimer-2 invariants -contain 2 ITAMs Immunoreceptor Tyr-based Activation Motifs -these signal when BCR binds antigen B Cell Activation Antigen cross-links BCRs ->clustering of BCRs/co-receptors ->Src family (Fyn, Blk, Lyn) activation (in lipid rafts) ->ITAM Tyr phos'ation by Src famliy ->Syk binds to beta phos'ated ITAMs ->Syk is phos'ated ->activate PLC, GEFs, CD19, BLNK, TCRs/co-receptors cluster ->initiate signaling ->recruit Lck ->activate Fyn (Src family) ->phos'ate ITAMs on zeta, CD3 ->ZAP-70 (Tyr Kinase) binds to zeta ITAMs ->ZAP-70 phos'ated by Lck ->ZAP-70 phos'ates LAT, SLP-76 ->SLP-76 activates PLC, GEFs, Tec kinases Then GEFs activate Ras, Rac ->activate MAP kinase cascade ->activate Fos->AP-1 x-factor, Antigen cross-links BCRs ->clustering of BCRs/co-receptors ->Src family (Fyn, Blk, Lyn) activation (in lipid rafts) ->ITAM Tyr phos'ation by Src famliy ->Syk binds to beta phos'ated ITAMs ->Syk is phos'ated ->activate PLC, GEFs, CD19, BLNK Then GEFs activate Ras, Rac ->activate MAP kinase cascade ->activate Fos->AP-1 x-factor, Phospholipase C phos'ation (contains SH domains) -PIP2-->IP3+DAG ->inc. cytosolic Ca++ ->activate calcineurin phosphatase ->activate NFAT x-factor ->Protein Kinase C activated ->x-factor NFkB Then Specific Gene xscription ->cell proliferation and diff'ation