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This Concept Map, created with IHMC CmapTools, has information related to: Types of Hypersensitivity, An example of a localized immune complex-mediated inflammatory response is an Arthus Reaction Allergic Alveolitis, deposit in local and systemic target tissues GI System, receptors on Target cell Destruction, IL-1 acts on Hypothalamus, Type I Allergy exposure to an environmental allergen results in disease or damage which can be immediate or delayed Eye reaction, IgM antibodies Type III Immune complex disease, An example of a localized immune complex-mediated inflammatory response is an Arthus Reaction Acute Glomerulonephritis, Innapropriate Blocking Eg. Anti-AChR Antibodies produced & block normal acetylcholine function at motor end plates of skeletal muscle., Platelet Activating Factor Leading to Leukocyte Adhesion, Prostaglandin Release causing Pain, deposit in local and systemic target tissues Nervous System, host self-antigens are altered causes idiopathic loss of tolerance, Antibodies produced by the humoral immune system in response to antigen exposure IgM, Histamine blocked by Autonomic Nervous System, Soluble Immune Complex Formation deposit in, Allergic Alveolitis ???? Poorly formed noncaseating interstitial granulomas & mononuclear cell infiltration Bronchiolitis, Alveolar Destruction, Dense Fibrosis, dyspnea, Weight loss Crepitant Rales, Fever, Fatigue, Type I Allergy exposure to an environmental allergen results in disease or damage which can be immediate or delayed Bronchopulmonary reactions, Complement cascade Classical pathway Membrane attack complex formed C5-9, Destruction Target cell malfunction, deposit in local and systemic target tissues Mast Cell Degranulation within each area of deposition