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This Concept Map, created with IHMC CmapTools, has information related to: PDC Deficiency_AmandaDraft, Pyruvate to Oxaloacetate, Phosphorylation allows for activity of the Pyruvate Dehydrogenase Complex, Lactic Acidemia as indicated by 5.7 mmol/L blood lactate, Lactate eventually leading to Lactic Acidemia, Pyruvate decreasing formation of Acetyl CoA, the random inactivation of one X chromosome during embryonic development leading to Variability in disease presentation, Mitochondria to provide substrates for gluconeogenesis, Pyruvate Dehydrogenase Complex impairment affects conversion of Pyruvate, Mother 26 years old gives birth to Ann, Acetyl CoA increasing oxidative phosphorylation, Ketone Bodies used to generate Acetyl CoA, Disease Management includes treatment with Dichloroacetate, Catabolism of CHO, Pyruvate exacerbating conversion to Lactate, Variability in disease presentation shown in different phenotypes of Ann, Phosphorylation allows for activity of the Pyruvate Dehydrogenase Complex, oxidative phosphorylation increasing the concentrations ATP, ATP perfered energy source of the Brain, oxidative phosphorylation resulting in decreased ATP/ADP ratio, Catabolism of Amino Acids