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This Concept Map, created with IHMC CmapTools, has information related to: Biochem A1 Hypercholesterolemia, intracellular cholesterol to Cholesteryl esters, Apo B/E receptors which recognize Apo B-100, size creating IDL, density creating IDL, receptor mediated endocytosis in clathrin coated pits, Lipoprotein lipase degrades triacylglycerol, triacylglycerol are assembled by microsomal transfer protein, cellular uptake of LDL results in decreased lysosomal release of cholesterol, ɚ% normal value of LDL receptor activity consistent with dx of homozygous FH, Macrophages becoming a foam cell, endothelial walls accumulating to form atherosclerotic plaque, elevated serum cholesterol levels of 1150 mg/dL, myocardial ischemia increasing risk for myocardial infarction, elevated serum cholesterol levels consistent with dx of homozygous FH, Apo B/E receptors which recognize Apo E, SREBPs bind to SRE-1, LDL receptor gene leading to elevated serum cholesterol levels, triacylglycerol increasing density, Nascent VLDL acquire Apo C-II, promoter region of LDL receptor gene