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This Concept Map, created with IHMC CmapTools, has information related to: SunburnBill.cmap, P53 pathway leading to transcription of P21, Production of CRF by hypothalamus which eventually leads to (through HPA pathway) Corticosteroid release, IL2 leads to cutaneous erythema, matrix metalloproteases degrade collagen, TNF alpha leads to stimulates bone marrow to mobilize leukocytes, Dermis Results in heat, TNF alpha leads to pain, counseling substance abuse, sodium may lead to hypertension, Medical school studies leads to Stress/anxiety, alcohol can lead to alcoholism, nutrients does take multi-vitamin, Loss of function of Desmoglein-1 or 3 Damages Desmosomes, CXCL8 leads to heat, macrophages leads to GM-CSF, saturated fat may lead to heart disease, cell cycle arrest via the P53 pathway, keratinocytes which lead to secretion of IL-1 alpha, mast cell degranulation leads to release of Histamine, Dermis Results in cutaneous erythema