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This Concept Map, created with IHMC CmapTools, has information related to: Turtle - gout, GMP converted by 5' nucleotidase to guanosine, treatments schedule follow up, Interleukin-1Beta (Il-1B) stimulates further release other inflammatory mediators, inflammation response if becomes a Chronic Inflammation, Chris Turtle diagnositics indicate needle shaped (monosodium urate) crystals in synovial fluid, adenosine Is converted by purine nucleoside phosphorylase to Hypoxanthine, High serum uric acid leads to needle shaped (monosodium urate) crystals in synovial fluid, Increased levels of PRPP leads to increased production of Purines, IMP participate in End-Product Feedback and inhibit PRPP amidotransferase, Inosine is converted to Hypoxanthine, Guanine is catalyzed by Xanthine oxidase to form Xanthine, PRPP is catalyzed by PRPP amidotransferase, hydrochlorothiazide is a water pill, signal transduction causing changes in adhesion molecules and chemokines expression, Chris Turtle diagnositics indicate borderline high creatine levels, water pill which contributes to dehydration, water loss, cytokines including Tumor Necrosis Factor alpha, Chris Turtle medication includes hydrochlorothiazide, treatments advise diet, kidney function because of high creatinine levels