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This Concept Map, created with IHMC CmapTools, has information related to: Rita Arthur, Rheumatoid Arthritis treat with NSAIDS, neutrophils secretes lysosomal enzymes, Helper T-Cells (CD4) stimulate macrophages, arachidonic acid creating leukotrienes, Bilateral wrist pain which started about 6 months ago, autoimmune disorder resulting in inflammatory response destroying hyaline cartilage, Chief Complaint presenting with elevated CRP (27mg/l), B-cells become Plasma Cell, immune complexes phagocytosed by macrophages, lysosomal enzymes resulting in tissue erosion, Family History of osteoporosis, Family History of type II diabetes, APC to present self anitgen to TCR, Family History of alcohol abuse, change in MHC II binding allowing APC, infiltration of leukocytes in synovium including B-cells, Rita Arthur has a Past Medical History, pro-inflammatory cytokines including IL7, Rita Arthur has a Family History, IL6 stimulates acute phase response & production of acrute phase proteins by liver