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This Concept Map, created with IHMC CmapTools, has information related to: Rita Arthur, Macrophages release TNF, Resists compression and reduces friction When chronically degraded leads to inflammation, Cytokines ???? RANKL, Treatment plan includes ????, Treatment plan includes Biological DMARDS, RANKL ???? Osteoclast production, Macrophages release IL-1, IL-6, Hyaline cartilage Which Resists compression and reduces friction, Rita Arthur 28 Caucasian F presents with Fever, pyrogens leading to Fever, CD4 T-cells have T-cell receptors that, HLA-DRB1 haplotype is associated with Rheumatoid Arthritis, NSAIDs (ibuprofen) for her inflammation, TNF Induces cells to produce Matrix Metalloproteinases, CD4 T-cells ???? results in autoimmune response, cytokines that include Il-6, Recognition of CCP as antigen Is presented by Dendritic Cells That carry MHC II molecules of the HLA-DRB1 haplotype, IFN-gamma activate Synoviocytes, NSAIDs (ibuprofen) inhibit COX (Cyclooxygenase), CD4 T-cells secrete IL-17