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This Concept Map, created with IHMC CmapTools, has information related to: Fragile X, can increase the repeats of the mutation making it more phenotypically severe, developmental delay but has normal IQ for age, developmental delays that rank at 38% and 47% of normal for age, 230 repeats leading to fragile X-syndrome, Premutation of FMR1 gene can result in Fragile X-Primary Ovarian Insufficiency (FXPOI), Southern Blot or PCR If the number is 55-230 CGG repeats, III-1 and III-2 (brothers) presents with patient history, patient history with a contributory family history mother II-3, more phenotypically severe which is called genetic anticipation, characteristic traits with physical large, everted ears, patient history has characteristic traits, characteristic traits with physical epileptic discharges, characteristic traits with behavioral hyperactive, Premutation of FMR1 gene results in a carrier for unstable FMR1 gene, developmental delays becomes mental retardation, carrier for unstable FMR1 gene present in mother, 55-230 CGG repeats is Premutation of FMR1 gene, "Neurite density/branching" may have implications in developmental delays, Hypermethylation of CpG island which can prevent Transcription/Translation of FMR1 gene, female carriers thus when passed on through x-linked inheritance can increase the repeats of the mutation