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This Concept Map, created with IHMC CmapTools, has information related to: Mark Davis~B6, proximal muscle atrophy marked by "mononuclear inflammatory cell infiltrate and invasion of "fatty connective tissue", calpains promotes muscle proteolysis, muscle membrane damage leads to inflammatory mediators in dystrophic muscle, X-Linked Inheritance (mutation) Which can Include Single Base Pair mutation, Western Blot can be used to determine presence and amount of defective Dystrophin, muscle biopsy proteins can be used in Western Blot, Mark Davis could undergo Novel therapies, Treatment plan includes Follow up visits to muscular dystrophy clinic, muscle proteolysis Which leads to Elevated Creatine Kinase, Dystrophin Protein Interacts with Dystroglycan complex proteins, Xp21 gene is Transcribed & Translated, mRNA with premature termination codon site resulting in Translation, Mark Davis Presents WIth Physical Developmental Delays, Developmental Delays On his mothers side May be related to an X-Linked Inheritance (mutation), muscle biopsy was used for Diagnostic Tests for DMD, Generalized motor atrophy Symptoms of Duchenne Muscular Dystrophy, pathologic entry of extracellular calcium into muscle fibers lead to excess cytosolic calcium signalling, Treatment plan includes Physical therapy, Woody Muscles Symptoms of Duchenne Muscular Dystrophy, calcium leakage of SR into cytosol lead to excess cytosolic calcium signalling