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This Concept Map, created with IHMC CmapTools, has information related to: B6~Gaucher Case, Gaucher disease which can be detected histologically as Gaucher cells, spleen, liver, bone morrow leads to hepatomegaly and splenaomegaly, size of macrophages causes Enlargement of spleen, glucose and ceramide which is basis for ????, accumulated glucocerebroside leading to "tissue paper appearance", heterozygous for allelic variants N370S and IVS2+1g-->A which means she could be either heteroallelic for the variants, accumulated glucocerebroside in Gaucher patient's lysosomes within Macrophages, normal hematopoietic tissue in bone contributes to decreased counts of Hemoglobin 12.5g/dl and reduced platelets, accumulated glucocerebroside crowds out normal hematopoietic tissue in bone, Patient's Parents of Ashkenazic Jewish descent (Genetic/family History), accumulated glucocerebroside within lysosomes, glucocerebrosidase activity within lysosomes, lysosomes leads to the swelling of lysosomes, size of macrophages causes Enlargement of liver, lysosomes of spleen, liver, bone morrow, Cell rupture releases cellular contents into lymphatics and blood stream, Patient who presents with Hemoglobin 12.5g/dl and reduced platelets, "mononuclear cells of reticuloendothelial system" are found within spleen, liver, bone morrow, "mononuclear cells of reticuloendothelial system" which have accumulated glucocerebroside, cellular contents into lymphatics and blood stream which can be identified by elevated ACP eyzme levels in serum