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This Concept Map, created with IHMC CmapTools, has information related to: Ned Morgan, neutorphils resulting in PMN infiltration, Ned Morgan complains of 10 days of "terrible, persistent cough", Ned Morgan complains of chills and fever, autolysin which destroys bacterial cells resulting in leakage of cell contents, macrophages which release stimulates IL-1, IL-6 and TNF-alpha, evading host defenses including gag reflex, Ned Morgan physical exam reveals T2-6 NRrSL, C3,4 ERSbR, IFN-gamma stimulates B cell isotype switching to IgG1 and IgG3, Blood cultures positive for gram-positive diplococci indicative of Streptococcus pneumoniae, Sputum culture positive for gram-positive diplococci, and PMNs often limited by contamination from oropharynx, proliferation and lysing of microorganisms which release cell contents, Ned Morgan lab work shows elevated white blood cell count (20,400), B cell activation produce antibodies, Ned Morgan is a 39 y/o male, stimulates cytokines including stimulates IL-1, IL-6 and TNF-alpha, Respiratory flouroquinolone such as Moxifloxacin, disrupts ciliated cells contributing to impaired mucociliary clearance, macrophages which release IL-8, Ned Morgan lab work shows Sputum culture positive for gram-positive diplococci, and PMNs, GM-CSM stimulates bone marrow