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This Concept Map, created with IHMC CmapTools, has information related to: Week 18, HCO3 Buffer system Leads to decreased HCO3 causing right shift in CO2 + H2O <--> H+ + HCO3, pH of 7.13 From Increased H+, working synergistically with CO leading to hypoxia, Pyruvate dehydrogenase complex and TCA cycle Causing Decreased oxygen consumption, Particulate Matter and Heat Lead to immune response, NADH/NAD+ inhibits Pyruvate dehydrogenase complex and TCA cycle, Smoke Inhalation Includes Particulate Matter and Heat, Lactic Acid production causing metabolic acidosis, Cytochrome Oxidase (complex IV) of ETC and inhibits Electron transport, hypoxia Treated with hyperbaric O2, Decreased oxygen consumption leading to Decreased respiratory A-V O2 pressure gradient, immune response resulting in acute inflammation, Smoke Inhalation Includes CN, 100 % saO2 from CO binds hemoglobin leading to false pulseox reading, Lactate Dehydrogenase producing Lactic Acid production, CN Binds to Cytochrome Oxidase (complex IV) of ETC, incrreased lactate from Lactic Acid production, stops ATP synthesis decreases ATP, pulmonary edema leads to decreased gas exchange, Smoke Inhalation Includes CO