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This Concept Map, created with IHMC CmapTools, has information related to: Hashimotos Thyroiditis, Todd Wilson presents with dry, scaly skin, result in a DECREASE in cardiac contractility because phospholamban is an inhibitor of Sarcoplasmic Reticulum Ca2+ ATPase which results in reduced SR calcium transport, reduced calcium flux into heart for myocyte, which ultimately leads to decreased Cardiac contractility, Hashimoto's Thyroiditis presents with recent weight gain, Todd Wilson has accumulation of glycosaminoglycans and hyaluronic acid in the dermis and joints which the mechanism is still not understood, DECREASE in thyroid hormone as a result from Hashimoto's thyroiditis which results in Increased expression levels of Phospholamban this increase of phospholamban will result in a DECREASE in cardiac contractility because phospholamban is an inhibitor of Sarcoplasmic Reticulum Ca2+ ATPase, anterior pituitary releases TSH, genomic effect-direct activation of transcription from DNA low levels of T3/4 low production of proteins, presentation of thyroid self-peptides to CD4+ T lymphocytes via antigen-presenting cells which activates pathways leading to increase in IL-2, CD4 T cell proliferation which can differentiate to TH2, Hashimoto's Thyroiditis presents with lethargy, T3 no negative feedback hypothalamus, IL-2 which stimulates CD4 T cell proliferation, Hashimoto's Thyroiditis presents with joint pain and swelling, reduced SR calcium transport, reduced calcium flux into heart for myocyte, which ultimately leads to decreased Cardiac contractility termed clinically as bradycardia, bone metabolism normally causes bone resorption, T4 no negative feedback hypothalamus, interferon gamma which can inhibit TH2, glycosaminoglycans and hyaluronic acid in the dermis and joints which the mechanism is still not understood but will lead to joint pain and swelling, T3 no negative feedback anterior pituitary, T4 no negative feedback anterior pituitary