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Este Cmap, tiene información relacionada con: MHC sheet, Th2 response HUMORAL, Structure of MHC-II Peptide binds to the cleft α1/β2 Structure α Chain with 2 domains: - α1 (variable) - α2 (constant) β Chain with 2 domains: - β1 (variable) - β2 (constant), MAJOR HISTOCOMPATIBILITY COMPLEX II MHC-II Function Presentation of peptides produced after PHAGOCYTOSIS and DIGESTION (into the fagolisosoma) of pathogens, Efectors T Cells depending on cytokines: IL-22, Consequence: Secretion of lytic enzymes by limph. CD8+, Efectors T Cells depending on cytokines: IL-12 IFNγ, MAJOR HISTOCOMPATIBILITY COMPLEX I MHC-I Structure Structure of MHC-I Peptide binds to the cleft α1/α2, MAJOR HISTOCOMPATIBILITY COMPLEX I MHC-I expressed by All nucleated cells, IL-12 IFNγ diferentiation to Th1, MAJOR HISTOCOMPATIBILITY COMPLEX I MHC-I Function Presentation of peptides produced after processing of citosollic peptides produced by the PROTEOSOMA, DIFERENTATION explicació QUAN ELS LIMFÒCIT TCD4+ SÓN ACTIVATS ES DIFERENCIEN EN: - CÈLS DE MEMÒRIA (QUEDEN ALS ORGANS LIMFOIDES) - CÈLS EFECTORES Aquestes cels efectores es diferencien en diferents sub-poblacions de limfòcits T (Th1, Th2, Th17, Treg) depenent de les citocines que "perceben". Les citocines que "perceben" provenen primerament de les citocines alliberades per les cels presentadores d'Ag (que recordeu son les primeres que troben l'Ag i a més de fagocitar-digerir-presentar, envien senyals en forma de citocines) Més tardanament les citocines majoritàries provenen de les pròpies cèls T activades., IL-4 diferentation to Th2, DIFERENTATION on Efectors T Cells, IMMUNOLOGICAL SYNAPSE Note that peptides presented via MHC-II are recognized by lymphocytes T CD4+ and MHC-I by CD8+ (T RESTRICTION) trought their TCR receptor. Other interactions are necessary for T activations MHC-I / CD8+ binding, IMMUNOLOGICAL SYNAPSE Note that peptides presented via MHC-II are recognized by lymphocytes T CD4+ and MHC-I by CD8+ (T RESTRICTION) trought their TCR receptor. Other interactions are necessary for T activations MHC-II / CD4+ binding, Consequences: ACTIVATION of TCD4+ and secretion of: - Citokines - Chemokines - Growth factors, Presentation of peptides produced after PHAGOCYTOSIS and DIGESTION (into the fagolisosoma) of pathogens Peptides are presented to TCD4+ cells IMMUNOLOGICAL SYNAPSE Note that peptides presented via MHC-II are recognized by lymphocytes T CD4+ and MHC-I by CD8+ (T RESTRICTION) trought their TCR receptor. Other interactions are necessary for T activations, ???? ???? ????, Efectors T Cells depending on cytokines: TGF-B, Structure of MHC-I Peptide binds to the cleft α1/α2 Structure α Chain with 3 domains: - α1 (variable) - α2 (constant) - α3 (constant. CD8 binding) β-2-microglobulin (constant)