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raceem wk 2, vitamin D deficiency leading to elevated PTH, increased bone resorption causing bone weakness, hypocalcemia causing hypocalcemic seizures, hypocalcemia inducing elevated PTH, vitamin D deficiency plays a role in normal neurological fuinction by the induction of neurotrophins and neurogenesis (eg-nerve growth factor, which binds to receptor tyrosine kinsases to provide a survival signal for different classes of neurons), being breast fed by Vitamin D deficient mother causes vitamin D deficiency, elevated PTH stimulates 1a hydroxylase in PT of kidney, Vit D binding nucleus & interaction with RXR leading to decreased expression of Ca absorption genes, 1a hydroxylase in PT of kidney which stimulates Vitamin D activation, being breast fed by Vitamin D deficient mother in part due to high levels of melanin in the skin block vitamin D synthesis