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Este Cmap, tiene informaciĆ³n relacionada con: bcr, IMMUNOGLOBULIN M + ALPHA and BETTA CHAINS ???? In the BCR the Ig is attached to chains alpha and betta than transduce intracellular signals for activation, HEAVY CHAINS somatic recombination of genes VDJ-C ????, ???? Consequences: SOMATIC RECOMBINATION OF H and L CHAINS GENERATES HIGH VARIABILITY ON VARIABLE DOMAINS, B CELL RECEPTOR consist on IMMUNOGLOBULIN M + ALPHA and BETTA CHAINS, Consist on: a) 2 heavy chains (H) each with 1 variable domain (Vh) and 3-4 constant domains (Ch) b) 2 Light chains (L) with 1 variable domain (Vl) and 1 constant domain (Cl) SOMATIC RECOMBINATION LIGHT CHAINS, ???? Consequences: SOMATIC RECOMBINATION OF H and L CHAINS GENERATES HIGH VARIABILITY ON VARIABLE DOMAINS, LIGHT CHAINS Somatic recombination of genes VJ-C ????, Consist on: a) 2 heavy chains (H) each with 1 variable domain (Vh) and 3-4 constant domains (Ch) b) 2 Light chains (L) with 1 variable domain (Vl) and 1 constant domain (Cl) SOMATIC RECOMBINATION HEAVY CHAINS, IMMUNOGLOBULIN M + ALPHA and BETTA CHAINS iG STRUCTURE Consist on: a) 2 heavy chains (H) each with 1 variable domain (Vh) and 3-4 constant domains (Ch) b) 2 Light chains (L) with 1 variable domain (Vl) and 1 constant domain (Cl), SOMATIC RECOMBINATION OF H and L CHAINS GENERATES HIGH VARIABILITY ON VARIABLE DOMAINS other mechanisms of variability includes: - COMBINATION OF H AND L (KAPPA OR LAMBDA) CHAINS- - UNION DIVERSITY - ALLELIC EXCLUSSION - SOMATIC HIPERMUTATION